Welcome to the CHELOUFI LAB
Our lab investigates epigenetic mechanisms of cellular plasticity using various ex-vivo and in-vivo mammalian reprogramming and differentiation systems. We focus on studying the underlying chromatin remodeling and regulatory RNA pathways and how they influence cell fate decisions in normal development and disease states. We combine a broad range of cellular assays, systems biology and biochemical approaches by developing various genetically engineered systems in embryonic stem cells, hematopoiesis, osteogenesis and neurogenesis. Using these platforms, we design functional assays and translate our findings clinically by using bioengineering tools, in-vivo mouse models and patient derived induced pluripotent stem cells (iPSCs). The ultimate goal of our research is to apply our finding to generate clinically relevant cell types, differentiate cancer cells and improve organismal life span.