Welcome to the CHELOUFI LAB
Our lab investigates epigenetic mechanisms of cellular plasticity using various ex-vivo and in-vivo mammalian reprogramming and differentiation systems. We study the underlying chromatin assembly and RNA processing pathways and how they influence cell fate decisions in normal development and disease states. We combine a broad range of genetics, genomics and biochemical approaches using various cell fate change paradigms including embryonic stem cells, hematopoiesis, osteogenesis and neurogenesis. Using these systems, we design functional assays and translate our findings clinically by using bioengineering tools, in-vivo mouse models and patient derived induced pluripotent stem cells (iPSCs). The ultimate goal of our research is to apply our finding to generate clinically relevant cell types, differentiate cancer cells and improve organismal life span.